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Trastuzumab, a monoclonal antibody that targets ERBB2, has improved treatment of this aggressive form of breast cancer [Slamon et ai. J Bone Joint Surg Am 2003;85A(suppl 3):8995. 15 (i) a100andd5. 9 Bcl-2 Proteins Regulate Mitochondrial Membrane Permeability Mitochondria occupy a central place in internal stress-induced apoptosis.
For example, the -adrenergic pathway that leads to el- evated levels of cytosolic cAMP, which acts as a second messenger in eukaryotes as well as in prokaryotes (see Figs 1212, 2818).
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